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Participation in clinical and epidemiological studies on nutrition

  

EPIDEMIOLOGICAL TRIALS

PREDIMED STUDY (Prevención con Dieta Mediterránea, www.predimed.org):

- STUDY DESIGN: Multicenter, randomized, controlled, parallel-group clinical trial, initially with 4 years of follow-up. An estimated 7500 participants  at high cardiovascular risk have been assigned to 3 interventions: 1) Mediterranean diet with virgin olive oil; 2) Mediterranean diet with mixed nuts; 3) control diet, low-fat diet following the "American Heart Association" guidelines.

- OBJECTIVE: To assess the effects of the Mediterranean diet in the primary prevention of cardiovascular disease. 

Epidemiological trials (PREDIMED)

    

    

EPIC STUDY (European Prospective Investigation into Cancer, www.epic-spain.com), thanks to the collaboration with Dr. Carlos Alberto Gonzalez Svatetz and Dr. Raul Zamora Ros.

- STUDY DESIGN: A prospective cohort and multicenter study coordinated by the International Agency for Research on Cancer (IARC), launched in 1992. In the Spanish cohort of the study 40,000 men and women aged between 35 and 70 have been included. Each of the participants were surveyed about their diet, a questionnaire onlifestyle and other factors, and anthropometric measurements and a blood samplewere collected.

- OBJECTIVE: Our partnership with the EPIC project focuses on the study of the association between consumption of polyphenols and cancer incidence.

    

    

InCHIANTI STUDY (Invecchiare nel Chianti, www.inchiantistudy.net), through collaboration with Dr. Antonio Cherubini.

- STUDY DESIGN: Prospective study which includes medical and functional data of two populations of the geographical region of Chianti (Italy).
- OBJECTIVE: Move epidemiological research in geriatric clinical tools that permit the realization of a more precise diagnosis and more effective treatment in older people with mobility problems. Our partnership with the InCHIANTI project focuses on the study of the effect of consumption of diets rich in phenolic compounds and their association with conditions associated with aging.

   

CLINICAL TRIALS

We are also participating in several prospective, crossed, controlled and randomized clinical trials to evaluate the beneficial effects of the intake of polyphenol-rich food (wine, cocoa, tea, citric fruits) on health in humans and animals. We have used this type of study because it offers the greatest level of scientific evidence.

   

ACUTE AND REGULAR INTAKE OF COCOA IN HUMANS, in collaboration with the Hospital Clínic of Barcelona.

ACUTE INTAKE STUDY:

- STUDY DESIGN: Open, prospective, randomized and crossover clinical trial, in which 21 healthy individuals were subjected to the following nutritional interventions: 1)intake of a single dose of 40g of cocoa powder mixed with 250ml of water, 2)intake of a single dose of 40g of cocoa powder mixed with 250ml of milk, 3) intake of 250ml of milk, after a wash-out period of 48 hours.

- OBJECTIE: To assess the bioavailability of phase II metabolites and microbiota of the cocoa polyphenols of cocoa, taking into account the effect of food matrix.

    

REGULAR CONSUMPTION STUDY:

- STUDY DESIGN: Controlled, prospective, randomized and crossover clinical trial, in which 42 healthy individuals were subjected to a period of "wash-out" followed by the following nutritional interventions: 1) intake of 500 mL of skimmed milk for 28 days , 2) two intakes of 20g cocoa powder mixed with 250ml of skimmed milk for 28 days.

- OBJECTIVE: To assess the bioavailability of phase II metabolites and microbiota of the cocoa polyphenols of cocoa, taking into account the effect of food matrix. To assess the inflammatory markers involved in atherosclerosis measuring the health impact of regular intake of soluble cocoa.

Clinical trials (cocoa)

   

   

MODERATE AND REGULAR CONSUMPTION OF WINE IN HUMANS, in collaboration with the Hospital Clínic of Barcelona.

- STUDY DESIGN: Controlled, prospective, randomized and crossover clinical trial, in which 72 men at high risk of cardiovascular events ingested a quantity of 30 grams of alcohol per day in form of red wine (alcoholic beverage with a high content of polyphenols ), gin (alcoholic drink without polyphenols), or the equivalent amount of alcohol-free red wine (non-alcoholic drink with a high content of polyphenols).

- OBJECTIVE: To determine the benefit/risk of a moderate and regular consumption of red wine and its relation to the amount of alcohol and/or polyphenols derived from grapes. To assess the positive effects on endothelial function and expression and function of monocyte adhesion molecules and endothelial cells, and the negative effects on the digestive system and liver. To relate the observed changes with the concentration of phenolic compounds found in plasma and urine, assessing the effect of the alcoholic matrix in its bioavailability.

Clinical trials (wine)

     

    

GROUP PUBLICATIONS

PREDIMED:

  • Zamora-Ros R et al. High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients. Pharmacological Research. 2012;65(6):615-620. PubMed
  • Urpi-Sarda M et al. Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomakers related to atherosclerosis. Pharmacological Research. 2012;65(6):577-583. PubMed
  • Urpi-Sarda M et al. Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomakers related to atherosclerosis. Pharmacological Research. 2012;65(6):577-583. PubMed
  • Medina-Remón A, Zamora-Ros R, Rotchés-Ribalta M, Andres-Lacueva C, Martínez-González MA, Covas MI, Corella D, Salas-Salvadó J, Gómez-Gracia E, Ruiz-Gutiérrez V, García de la Corte FJ, Fiol M, Pena MA, Saez GT, Ros E, Serra-Majem L, Pinto X, Warnberg J, Estruch R, Lamuela-Raventos RM; on behalf of the PREDIMED Study Investigators. Total polyphenol excretion and blood pressure in subjects at high cardiovascular risk. Nutrition, Metabolism, and Cardiovascular Diseases.2011;21(5):323-331. PubMed
  • Zamora-Ros R, Urpí-Sardà M, Lamuela-Raventós RM, Estruch R, Martínez-González MA, Bulló M, Arós F, Cherubini A, Andres-Lacueva C. Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: The PREDIMED Study. Free Radical & Biology Medicine. 2009;46(12):1562-1566. PubMed
  • Medina-Remón A, Barrionuevo-González A, Zamora-Ros R, Andres-Lacueva C, Estruch R, Martínez-González MA, Diez-Espino J, Lamuela-Raventos RM. Rapid Folin-Ciocalteu method using microtiter 96-well plate cartridges for solid phase extraction to assess urinary total phenolic compounds, as a biomarker of total polyphenols intake. Analytica Chimica Acta. 2009;634(1):54-60. PubMed

 

EPIC-Spain:

  • Zamora-Ros R, Andres-Lacueva C, Lamuela-Raventós RM, Berenguer T, Jakszyn P, Barricarte A, Ardanaz E, Amiano P, Dorronsoro M, Larrañaga N, Martínez C, Sánchez MJ, Navarro C, Chirlaque MD, Tormo MJ, Quirós JR, González CA. Estimation of dietary sources and flavonoid intake in a Spanish adult population (EPIC-Spain). Journal of American Dietetic Association. 2010;110(3):390-398. PubMed
  • Zamora-Ros R, Andres-Lacueva C, Lamuela-Raventós RM, Berenguer T, Jakszyn P, Martínez C, Sánchez MJ, Navarro C, Chirlaque MD, Tormo MJ, Quirós JR, Amiano P, Dorronsoro M, Larrañaga N, Barricarte A, Ardanaz E, González CA. Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort. British Journal of Nutrition. 2008;100(1):188-196. PubMed

 

InCHIANTI Study:

  • Montserrat Rabassa, Antonio Cherubini, Raul Zamora-Ros, Mireia Urpi-Sarda, Stefania Bandinelli, Luigi Ferrucci, Cristina Andres-Lacueva. Low levels of a urinary biomarker of dietary polyphenol are associated with substantial cognition decline over a three-year period in older adults: the Invecchiare in Chianti (InCHIANTI) Study. JAGS. 2014. Accepted.

  • Mireia Urpi-Sarda, Cristina Andres-Lacueva, Montserrat Rabassa, Carmelinda Ruggiero, Raul Zamora-Ros, Stefania Bandinelli, Luigi Ferrucci, Antonio Cherubini. The Relationship between Urinary Total Polyphenols and Frailty in a Community-Dwelling Older PopulationThe journals of gerontology. Series A, Biological sciences and medical sciences. 2014. Accepted. 

  • Semba RD; Ferrucci L; Bartali B; Urpi-Sarda M; Zamora-Ros R; Sun K; Cherubini A; Bandinelli S; Andres-Lacueva C. Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults. JAMA Intern Med. 2014;174(7):1077-84. PubMed

  • Zamora-Ros R et al. High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults. Journal of Nutrition. 2013; 143 (9): 1445-1450.  PubMed

  • Zamora-Ros R, Rabassa M, Cherubini A, Urpi-Sarda M, Llorach R, Bandinelli S, Ferrucci L, Andres-Lacueva C (2011) Comparison of 24-h volume and creatinine-corrected total urinary polyphenol as a biomarker of total dietary polyphenols in the InCHIANTI Study Analytica Chimica Acta. 2011;704(1-2):110-115. PubMed

  • Abbatecola AM, Cherubini A, Guralnik JM, Andres-Lacueva C, Ruggiero C, Maggio M, Bandinelli S, Paolisso G, Ferrucci L. Plasma polyunsaturated fatty acids and age-related physical performance decline. Rejuvenation Research. 2009;12(1):25-32. PubMed
  • Cherubini, A.; Andrés-Lacueva, C.; Martin, A.; Lauretani, F.; Di Iorio, A.; Bartali, B.; Corsi, A.; Bandinelli, S.; Mattson, M.P.; Ferrucci, L. Low plasma n-3 fatty acids and dementia in older persons: The InCHIANTI study. Journals of Gerontology Series A - Biological Sciences and Medical Sciences. 2007; 62(10): 1120 – 1126. PubMed
  • Ferrucci L, Cherubini A, Bandinelli S, Bartali B, Corsi A, Lauretani F, Martin A, Andres-Lacueva C, Senin U, Guralnik JM. Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metab. 2006; 91(2):439-46. PubMed
  • Di Iorio A, Cherubini A, Volpato S, Sparvieri E, Lauretani F, Franceschi C, Senin U, Abate G, Paganelli R, Martin A, Andres-Lacueva C, Ferrucci L. Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study. Neurobiology of Aging. 2006;27(9):1280-1288. PubMed
  • Cherubini A, Martin A, Andres-Lacueva C, Di Iorio A, Lamponi M, Mecocci P, Bartali B, Corsi A, Senin U, Ferrucci L. Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study. Neurobiology of Aging. 2005;26(7):987-994. PubMed
  • Cherubini A, Martin A, Andres-Lacueva C, Grossi E, Paniagua M, Ercolani S, Mecocci P, Di lorio A, Senin U, Ferrucci L. Livelli plasmatici di vitamina E (a e g tocoferolo) nella popolazione dello studio inCHIANTI. Giornale di Gerontology. 2001;49:348-349.

 

Cocoa Study: 

 

Wine Study:

  • Boto-Ordoñez M et al. Microbial metabolomic fingerprinting in urine after regular dealcoholized red wine consumption in humans Journal of Agricultural and Food Chemistry. 2013 [in press].
  • Jiménez-Girón A et al. Comparative Study of Microbial-Derived Phenolic Metabolites in Human Feces after Intake of Gin, Red Wine, and Dealcoholized Red Wine. Journal of Agricultural and Food Chemistry. 2013;61(16):3909-3915. PubMed
  • Khan N et al. Regular consumption of cocoa powder with milk increases HDL cholesterol and reduces oxidized LDL levels in subjects at high-risk of cardiovascular diseaseNutrition, Metabolism & Cardiovascular Diseases. 2012;22(12):1046-1053. PubMed
  • Rotches-Ribalta M et al. Gut and microbial resveratrol metabolite profiling after moderate long-term consumption of red wine versus dealcoholized red wine in humans by an optimized ultra-high-pressure liquid chromatography tandem mass spectrometry method. Journal of Chromatography A. 2012;1265: 105-113. doi: 10.1016/j.chroma.2012.09.093.  PubMed
  • Rotches-Ribalta M et al. Gut and microbial resveratrol metabolite profiling after moderate long-term consumption of red wine versus dealcoholized red wine in humans by an optimized ultra-high-pressure liquid chromatography tandem mass spectrometry method. Journal of Chromatography A. 2012;1265: 105-113. doi: 10.1016/j.chroma.2012.09.093.  PubMed
  • Chiva-Blanch G et al. Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial. Clinical Nutrition. 2013;32(2):200-206. PubMed
  • Chiva-Blanch G et al. Dealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide. Circulation Research. 2012;111(8):1065-1068. PubMed
  • Chiva-Blanch G et al. Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial. American Journal of Clinical Nutrition. 2012;95(2):326-334. PubMed
  • Martinez N, Urpi-Sarda M, Martinez-Gonzalez MA, Andres-Lacueva C, Mitjavila MT. Dealcoholised beers reduce atherosclerosis and expression of adhesion molecules in apoE-deficient mice. British Journal of Nutrition. 2011;105(5):721-730. PubMed
  • Chiva-Blanch G, Urpi-Sarda M, Rotchés-Ribalta M, Zamora-Ros R, Llorach R, Lamuela-Raventós RM, Estruch R, Andrés-Lacueva C. Determination of resveratrol and piceid in beer matrices by solid-phase extraction and liquid chromatography-tandem mass spectrometry. Journal of Chromatography. A. 2011;1218(5):698-705. PubMed
  • Estruch R, Sacanella E, Mota F, Chiva-Blanch G, Antúneza E, Casals E, Deulofeu R, Rotilio D, Andres-Lacueva C, Lamuela-Raventos RM, de Gaetano G, Urbano-Marquez A. Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: A randomised cross-over trial. Nutrition Metabolism and Cardiovascular Diseases. 2011;21(1):46-53. PubMed
  • Ortuno J, Covas MI, Farre M, Pujadas M, Fito M, Khymenets O, Andres-Lacueva C, Roset P, Joglar J, Lamuela-Raventos RM, de la Torre R. Matrix effects on the bioavailability of resveratrol in humans. Food Chemistry. 2010;120(4):1123-1130. ScienceDirect
  • Zamora-Ros R, Andres-Lacueva C, Lamuela-Raventós RM, Berenguer T, Jakszyn P, Barricarte A, Ardanaz E, Amiano P, Dorronsoro M, Larrañaga N, Martínez C, Sánchez MJ, Navarro C, Chirlaque MD, Tormo MJ, Quirós JR, González CA. Estimation of dietary sources and flavonoid intake in a Spanish adult population (EPIC-Spain). Journal of American Dietetic Association. 2010;110(3):390-398. PubMed
  • Andres-Lacueva C, Zamora-Ros R. Wanted: specific nutritional biomarkers for food consumption for the study of its protective role in health. British Journal of Nutrition. 2010;103(3):307-308. PubMed
  • Monagas M, Khan N, Andrés-Lacueva C, Urpí-Sardá M, Vázquez-Agell M, Lamuela-Raventós RM, Estruch R. Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells. British Journal of Nutrition. 2009;102(2):201-206. PubMed
  • Zamora-Ros R, Urpí-Sardà M, Lamuela-Raventós RM, Estruch R, Martínez-González MA, Bulló M, Arós F, Cherubini A, Andres-Lacueva C. Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: The PREDIMED Study. Free Radical Biology & Medicine. 2009;46(12):1562-1566. PubMed
  • Zamora-Ros R, Lamuela-Raventós RM, Estruch R, Andres-Lacueva C. Resveratrol, a new biomarker of moderate wine intake? British Journal of Nutrition. 2009;101(1):148. PubMed
  • Zamora-Ros R, Andres-Lacueva C, Lamuela-Raventós RM, Berenguer T, Jakszyn P, Martínez C, Sánchez MJ, Navarro C, Chirlaque MD, Tormo MJ, Quirós JR, Amiano P, Dorronsoro M, Larrañaga N, Barricarte A, Ardanaz E, González CA. Concentrations of resveratrol and derivates in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort. British Journal of Nutrition. 2008;100(1):188-196. PubMed
  • Darias-Martin JJ, Andres-Lacueva C, Diaz-Romero C, Lamuela-Raventos RM. Phenolic profile in varietal white wines made in the Canary Islands. European Food Research & Technology. 2008;226(4):871-876. Abstract
  • de Andrés-de Prado R, Yuste-Rojas M, Sort X, Andrés-Lacueva C, Torres M, Lamuela-Raventós RM. Effect of soil type on wines produced from Vitis vinifera L. cv. Grenache in commercial vineyards. Journal of Agricultural and Food Chemistry. 2007;55(3): 779-786.
  • Vázquez-Agell M, Sacanella E, Tobias E, Monagas M, Antúnez E, Zamora-Ros R, Andrés-Lacueva C, Lamuela-Raventós RM, Fernández-Solá J, Nicolás JM, Estruch R. Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk. Journal of Nutrition. 2007;137(10):2279-2284. PubMed
  • Urpi-Sarda M, Zamora-Ros R, Lamuela-Raventos R, Cherubini A, Jauregui O, de la Torre R, Covas MI, Estruch R, Jaeger W, Andres-Lacueva C. HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humans. Clinical Chemistry. 2007;53(2):292-299. PubMed
  • Zamora-Ros R, Urpí-Sardà M, Lamuela-Raventós RM, Estruch R, Vázquez-Agell M, Serrano-Martínez M, Jaeger W, Andres-Lacueva C. Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption. Clinical Chemistry. 2006;52(7):1373-1380. PubMed
  • Urpí-Sardà M, Jáuregui O, Lamuela-Raventós RM, Jaeger W, Miksits M, Covas MI, Andres-Lacueva C. Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry. Analytical Chemistry. 2005;77(10):3149-3155. PubMed

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Open call: postdoctoral grants BP-B 

    

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