Capacities

Development of human intervention studies & clinical trials in hospitals
Diet analysis & estimation of phytochemical intake
Design & implementation of metabolomics analysis protocol
High-throughput food & biological sample analysis
Bioinformatics & biostatistical tools: computational-assisted biomarkers identification & biological interpretation

MASS SPECTROMETRY PLATFORM for metabolomic analysis of biomarkers and metabolic profiles:

Targeted metabolomic analysis conducted by:
- LC-MS/MS triple quadrupole for targeted detection and quantification of biomarkers of intake and health by MRM: UHPLC-QqQ-MS/MS (API 3000)
- High sensitivity QTRAP Technology for targeted detection and quantification of biomarkers of intake and health with capacity for producing MS³ fragmentation (API 4000, API 6500)
Non-targeted metabolomic analysis by LC-MS: HPLC-ESI-Q-ToF-MS (QSTAR Elite)
Identification/confirmation of potential biomarkers using MSⁿ fragmentations: UHPLC-LTQ-FT-Orbitrap MS (LTQ Orbitrap Velos). BIORMARKER PANEL (metabolite groups up to 600 validated biomarkers).

NUCLEAR MAGNETIC RESONANCE PLATFORM for global analysis of metabolic profile:

NMR-driven metabolomics target analysis: Varian Inova 500 MHz Bruker Avance III 600 MHz
Identification and quantification of a validated biomarkers panel in biological samples (from 70/80 metabolites)